Genetic Bases for Glaucoma
نویسندگان
چکیده
منابع مشابه
Genetic Epidemiology of Glaucoma
Purpose. The genetic etiology of primary open-angle glaucoma (POAG) is still largely unknown, because of its complexity and disparities in its classification. We aimed to determine the genetic contribution to various early, continuous markers of POAG by assessing the heritability of intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, and neuroretinal rim and optic disc param...
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Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive trait, or as a complex multifactorial trait. Genetic approaches have helped define the underlying molecular events responsible for some mendelian forms of the disease and have identified the chromosome locations of genes that are likely to contribute to common complex forms. Future directions include the discover...
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This article reviews the concept of an endophenotype, with particular reference to heritability as well as diagnostic specificity. An endophenotype need not be heritable, for example, the possible influence of in utero viral infections for schizophrenia. However, heritability is a useful characteristic for a potential endophenotype, as it can be studied in relation to a plausible candidate gene...
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A number of genetic polymorphisms have been investigated in Negro and Caucasoid patients with glaucoma and the results compared with data obtained on healthy controls. A sample of 61 Negro patients was not significantly different from a sample of 238 controls with respect to 18 red cell and serum protein systems; no association between glaucoma and any of these systems could be demonstrated. Th...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 2010
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.221.1